Facile and highly efficient synthesis of fluorinated heterocycles via Prins cyclization in ionic liquid hydrogen fluoride salts

Yuichiro Kishi; Hirokatsu Nagura; Shinsuke Inagi; Toshio Fuchigami

doi:10.1039/b806389c

Facile and highly efficient synthesis of fluorinated heterocycles via Prins cyclization in ionic liquid hydrogen fluoride salts

Chem Commun (Camb). 2008 Sep 7:(33):3876-8. doi: 10.1039/b806389c. Epub 2008 Jun 24.

Authors

Yuichiro Kishi¹, Hirokatsu Nagura, Shinsuke Inagi, Toshio Fuchigami

Affiliation

¹ Department of Electronic Chemistry, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama, Japan.

PMID: 18726020
DOI: 10.1039/b806389c

Abstract

Prins cyclization of homoallylic alcohols, thiols, and amines with various aldehydes in an ionic liquid HF salt (Et(4)NF.5HF) afforded the corresponding 4-fluorinated heterocycles in excellent yields.