Review
doi: 10.1007/s00018-008-8352-3.
Membrane fusion: SNAREs and regulation
Affiliations
- PMID: 18726177
- PMCID: PMC11131752
- DOI: 10.1007/s00018-008-8352-3
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Review
Membrane fusion: SNAREs and regulation
Cell Mol Life Sci.
2008 Sep.
Abstract
SNARE (SNAP receptor) proteins drive intracellular membrane fusion and contribute specificity to membrane trafficking. The formation of SNAREpins between membranes is spatially and temporally controlled by a network of sequentially acting accessory components. These regulators add an additional layer of specificity, arrest SNAREpin intermediates, lower the energy required for fusion, and couple membrane fusion to triggering signals. The functional activity of some of these regulators determines the plasticity of regulated exocytosis.
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