[Compensatory and antiamnestic effects of heptapeptide Selank in monkeys]

Zh Evol Biokhim Fiziol. May-Jun 2008;44(3):284-90.
[Article in Russian]

Abstract

The work presents results of study of role of heptapeptide Selank--an anxiolytic from group of biologically active peptides--in compensation of disturbed psychic and homeostatic functions in monkeys. New data have been obtained which indicate that an intranasal administration of Selank produces long-term changes of the monkeys' behavior disturbed during neurosis: elimination of fear and aggression and an increase of orientational-explorative activity as well as facilitation of handling reactions and communicational relations. It has been established that on the background of the Selank there occurs a long compensation of disturbed psychic functions (processes of memory) and of homeostatic parameters. It has been shown that unlike the earlier studied neurohormones (thyroliberin and ACTH4-10), the antistressor Selank effects do not depend on the type of neurotic disturbances and have long-term compensatory character. Comparison of the data obtained on monkeys with results of similar studies on the more low-organized mammals (rodents) allow suggesting that the new peptide preparation Selank is a promising agent for correction of various psychoemotional disturbances (alarm- and depression-like disorders).

MeSH terms

  • Aggression / drug effects*
  • Amnesia / drug therapy*
  • Animals
  • Behavior, Animal / drug effects*
  • Depression / drug therapy
  • Drug Evaluation, Preclinical
  • Fear / drug effects*
  • Female
  • Macaca mulatta
  • Male
  • Memory / drug effects*
  • Oligopeptides / pharmacology*
  • Oligopeptides / therapeutic use

Substances

  • Oligopeptides
  • TP 7