Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss

J Clin Endocrinol Metab. 2008 Nov;93(11):4479-85. doi: 10.1210/jc.2008-1505. Epub 2008 Aug 26.

Abstract

Context: There are very limited data available concerning the relationships between fetuin-A, weight status, nonalcoholic fatty liver disease (NAFLD), and features of the metabolic syndrome (MetS) in obese humans, and especially in children.

Objective: Our objective was to study the longitudinal relationships between fetuin-A, NAFLD, and MetS in obese children.

Design: This was a 1-yr longitudinal follow-up study.

Setting: This study was performed in primary care.

Patients: A total of 36 obese and 14 lean children was included in the study.

Intervention: An outpatient 1-yr intervention program based on exercise, behavior, and nutrition therapy was performed.

Main outcome measures: Changes of weight status (sd score-body mass index), waist circumference, fetuin-A, blood pressure, lipids, transaminases, insulin resistance index homeostasis model assessment (HOMA), and prevalence of NAFLD (defined by liver ultrasound) were calculated.

Results: The 12 obese children with NAFLD had significantly higher fetuin-A levels (0.35+/-0.07 g/liter) than the 24 obese children without NAFLD (0.29+/-0.06 g/liter) and the 14 normal weight children (0.29+/-0.05 g/liter). Fetuin-A levels were independent of age, pubertal stage, and gender. Fetuin-A correlated significantly to systolic (r=0.50) and diastolic blood pressure (r=0.41), insulin resistance index HOMA (r=0.28), and high-density lipoprotein-cholesterol (r=-0.31). Changes of fetuin-A correlated significantly to changes of insulin resistance index HOMA (r=0.34), systolic (r=0.31) and diastolic blood pressure (r=0.37), and waist circumferences (r=0.36). Substantial weight loss in 21 children led to a significant decrease of fetuin-A and the prevalence of NAFLD in contrast to the 15 children without substantial weight loss.

Conclusions: Fetuin-A levels were higher in children with NAFLD, and were related to insulin resistance and to features of the MetS in both cross-sectional and longitudinal analyses. Therefore, fetuin-A might be a new promising link between obesity and its comorbidities.

Trial registration: ClinicalTrials.gov NCT00435734.

MeSH terms

  • Behavior Therapy
  • Blood Glucose / metabolism
  • Blood Pressure
  • Blood Proteins / metabolism*
  • Body Mass Index
  • Child
  • Exercise
  • Fatty Liver / blood*
  • Fatty Liver / complications
  • Female
  • Follow-Up Studies
  • Humans
  • Insulin / blood
  • Lipids / blood
  • Male
  • Metabolic Syndrome / blood*
  • Obesity / blood*
  • Puberty
  • Reference Values
  • Weight Loss*
  • alpha-2-HS-Glycoprotein

Substances

  • AHSG protein, human
  • Blood Glucose
  • Blood Proteins
  • Insulin
  • Lipids
  • alpha-2-HS-Glycoprotein

Associated data

  • ClinicalTrials.gov/NCT00435734