[A case of ABO*Ael02/O04 genotype with typical phenotype O]

Korean J Lab Med. 2008 Aug;28(4):319-24. doi: 10.3343/kjlm.2008.28.4.319.
[Article in Korean]


Ael is a rare blood type which has the least amount of A antigen among A subgroups. It can be detected by special tests performed to resolve the discrepancy between red cell and serum typing in routine serological typing. The presence of A antigen on Ael red cell is demonstrable only by adsorption and elution tests. An Ael individual does not secret A substance in the saliva and may have anti-A antibody in the serum which is usually less reactive with the reagent red cells than anti-B antibody. In Korea, Ael02 has been reported more frequently than other Ael alleles. We report a case of Ael02/O04 who presented as typical phenotype O with strong anti-A and anti-B antibodies and no A antigen detected even by adsorption and elution tests. The case has been proved to be Ael02/O04 by direct sequencing analysis. In individuals with history of discrepancies in the results of ABO phenotyping, ABO genotyping is needed for an accurate evaluation of their blood type.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • ABO Blood-Group System / classification
  • ABO Blood-Group System / genetics*
  • Alleles
  • Child
  • Genotype
  • Heterozygote
  • Humans
  • Male
  • Pedigree
  • Phenotype
  • Sequence Analysis, DNA


  • ABO Blood-Group System