A Polygenic Model With Common Variants May Predict Lung Adenocarcinoma Risk in Humans

Int J Cancer. 2008 Nov 15;123(10):2327-30. doi: 10.1002/ijc.23789.


Genome-wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single-nucleotide polymorphism (SNP) array, in a joint analysis of 2 Italian case-control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6-0.8]. In a polygenic model characterized by additive and interchangeable effects, individuals carrying 2 to 6 rare alleles at these 8 SNPs showed a significant trend toward a decreased risk of lung ADCA (up to OR of 0.3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / genetics*
  • Adult
  • Aged
  • Chromosome Mapping
  • Female
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Lung Neoplasms / genetics*
  • Male
  • Middle Aged
  • Models, Genetic*
  • Polymorphism, Single Nucleotide
  • Smoking