In vivo imaging of abdominal aortic aneurysms: increased FDG uptake suggests inflammation in the aneurysm wall

J Endovasc Ther. 2008 Aug;15(4):462-7. doi: 10.1583/08-2447.1.

Abstract

Purpose: To study the potential of integrated positron emission tomography and computed tomography (PET/CT) to identify aneurysm wall inflammation.

Methods: The level of F18-fluorodeoxyglucose (FDG) uptake was studied in aneurysmal and normal-sized aortas of 34 male patients [17 with abdominal aortic aneurysm (AAA) and 17 age-matched controls] identified in a database of 278 consecutive patients evaluated for staging of primary lung cancer. The maximal standardized uptake value (SUV) was calculated to quantify FDG uptake in the AAA wall.

Results: AAAs showed significantly higher FDG uptake than the normal-sized aorta in age-matched controls (SUV 2.52+/-0.52 versus 1.78+/-0.45, respectively; p<0.001). The level of FDG uptake did not correlate with maximal aneurysm diameter (r=0.09; 95% CI -0.42 to 0.56; p=0.7).

Conclusion: FDG-PET/CT is a promising technique to identify inflammation of the aneurysm wall. Irrespective of aneurysm diameter, asymptomatic AAAs show more FDG uptake and more inflammatory activity in the wall than the non-dilated abdominal aorta of sex/age-matched controls. Future studies will be directed at the predictive value of increased FDG uptake for aneurysm wall strength, rupture risk, and the utility of FDG-PET/CT in assessing the effect of medical interventions.

MeSH terms

  • Aged
  • Aortic Aneurysm, Abdominal / diagnostic imaging*
  • Case-Control Studies
  • Fluorodeoxyglucose F18*
  • Humans
  • Inflammation / diagnostic imaging
  • Male
  • Radiopharmaceuticals*
  • Tomography, Emission-Computed*
  • Tomography, X-Ray Computed

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18