Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease

J Infect Dis. 2008 Oct 15;198(8):1166-70. doi: 10.1086/592053.


Increases in the incidence and severity of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have spawned efforts to define unique virulence properties among prevalent strains. Panton-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered attention because of its epidemiologic association with CA-MRSA. Using both the clinical isolate LAC, which is representative of the epidemic USA300 strain, and its isogenic PVL-negative strain in murine models of staphylococcal skin infection and pneumonia, we expanded upon recent studies by assessing the contribution of PVL in the genetic background of BALB/c mice. The data presented in this report support the observation that PVL does not contribute to the pathogenesis of staphylococcal infection of mice.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Animals
  • Bacterial Toxins* / genetics
  • Bacterial Toxins* / metabolism
  • Community-Acquired Infections / microbiology
  • Community-Acquired Infections / pathology*
  • Disease Models, Animal
  • Exotoxins* / genetics
  • Exotoxins* / metabolism
  • Female
  • Humans
  • Leukocidins* / genetics
  • Leukocidins* / metabolism
  • Methicillin Resistance*
  • Mice
  • Mice, Inbred BALB C
  • Mutation
  • Pneumonia, Staphylococcal / microbiology
  • Pneumonia, Staphylococcal / mortality
  • Pneumonia, Staphylococcal / pathology*
  • Staphylococcal Skin Infections / microbiology
  • Staphylococcal Skin Infections / pathology*
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / genetics
  • Staphylococcus aureus / isolation & purification
  • Staphylococcus aureus / pathogenicity*
  • Virulence


  • Bacterial Toxins
  • Exotoxins
  • Leukocidins
  • Panton-Valentine leukocidin