Abstract
Administration of[3H]aflatoxin B2 (2,3-dihydroaflatoxin B1)(AFB2) to male rats resulted in levels of hepatic DNA- and ribosomal(r)RNA-aflatoxin adducts that were about 1% of those for rats given [3H]aflatoxin B1(AFB1). The levels of hepatic protein-aflatoxin adducts were 35 to 70% as great for AFB2-treated as compared to AFB1-treated rats...
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aflatoxins / metabolism*
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Aflatoxins / toxicity
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Animals
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Carcinogens
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Carcinoma, Hepatocellular / chemically induced
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DNA / metabolism*
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Intestine, Small / metabolism
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Kidney / metabolism
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Liver / metabolism*
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Liver Neoplasms / chemically induced
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Male
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Neoplasms, Experimental / chemically induced
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Oxides / metabolism
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Phenobarbital / pharmacology
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Pituitary Gland / physiology
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Protein Binding
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RNA, Ribosomal / metabolism*
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Rats
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Spleen / metabolism
Substances
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Aflatoxins
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Carcinogens
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Oxides
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RNA, Ribosomal
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DNA
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Phenobarbital