Aflatoxin B1-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo

Cancer Res. 1977 Jan;37(1):172-81.

Abstract

Administration of[3H]aflatoxin B2 (2,3-dihydroaflatoxin B1)(AFB2) to male rats resulted in levels of hepatic DNA- and ribosomal(r)RNA-aflatoxin adducts that were about 1% of those for rats given [3H]aflatoxin B1(AFB1). The levels of hepatic protein-aflatoxin adducts were 35 to 70% as great for AFB2-treated as compared to AFB1-treated rats...

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aflatoxins / metabolism*
  • Aflatoxins / toxicity
  • Animals
  • Carcinogens
  • Carcinoma, Hepatocellular / chemically induced
  • DNA / metabolism*
  • Intestine, Small / metabolism
  • Kidney / metabolism
  • Liver / metabolism*
  • Liver Neoplasms / chemically induced
  • Male
  • Neoplasms, Experimental / chemically induced
  • Oxides / metabolism
  • Phenobarbital / pharmacology
  • Pituitary Gland / physiology
  • Protein Binding
  • RNA, Ribosomal / metabolism*
  • Rats
  • Spleen / metabolism

Substances

  • Aflatoxins
  • Carcinogens
  • Oxides
  • RNA, Ribosomal
  • DNA
  • Phenobarbital