Angiotensin II stimulates angiogenesis in the chorio-allantoic membrane of the chick embryo

Eur J Pharmacol. 1991 Mar 26;195(2):305-6. doi: 10.1016/0014-2999(91)90552-2.


Angiotensin II was applied daily in doses of 67 or 670 ng to a section of the chick embryo chorio-allantoic membrane from day 7 to day 14 after fertilization of the eggs. During this one-week period, it caused a significant, dose-dependent increase in the vascular density index. The increase obtained with 670 ng daily was comparable to that after daily administration of 1.7 micrograms adenosine, a known stimulator of angiogenesis. The data suggest a possible role for angiotensin II as a mediator of vascular growth.

MeSH terms

  • Allantoin
  • Angiotensin II / pharmacology
  • Angiotensin II / physiology*
  • Animals
  • Blood Vessels / drug effects
  • Blood Vessels / growth & development*
  • Chick Embryo
  • Chorion / blood supply
  • Chorion / drug effects


  • Angiotensin II
  • Allantoin