1,25-Dihydroxycholecalciferol inhibits the cochemotactic activity of Gc (vitamin D binding protein)

J Endocrinol Invest. 1991 May;14(5):405-8. doi: 10.1007/BF03349090.


The identification of Gc (vitamin D binding protein) with the anionic polypeptide cochemotaxin has recently been reported. In this paper we investigate its dose dependent cochemotactic activity and report the inhibition of Gc enhanced chemotaxis by vitamin D3. These results further support the role of immunomodulating hormone played by vitamin D.

MeSH terms

  • Adjuvants, Immunologic / pharmacology
  • Calcitriol / pharmacology*
  • Calcitriol / physiology
  • Cell Movement / drug effects
  • Cell Movement / physiology
  • Chemotaxis / drug effects*
  • Chemotaxis / physiology
  • Dose-Response Relationship, Drug
  • Humans
  • Leukocytes / drug effects
  • Leukocytes / physiology
  • Vitamin D-Binding Protein / physiology*


  • Adjuvants, Immunologic
  • Vitamin D-Binding Protein
  • Calcitriol