Inhibition of growth and induction of differentiation of colon cancer cells by peach and plum phenolic compounds

Anticancer Res. 2008 Jul-Aug;28(4B):2067-76.


The action of extracts from anthocyanin-enriched plums and peaches on growth and differentiation was studied with human colon cancer cells. Growth inhibitory effects were observed in Caco-2, SW1116, HT29 and NCM460 cells. In Caco-2 cells but not in the other cells studied there was evidence for increased differentiation as judged by increased activity of alkaline phosphatase and dipeptidyl peptidase. A differentiating effect on Caco-2 cells was not seen with cyanidin or cyanidin-3-glucoside but the action of the fruit extracts was additive with the action of butyrate and with the MEK1/2 inhibitor U0126. Fractionation using C18 indicated activity resided within a fraction containing anthocyanins but further fractionation using LH-20 suggested that most of the activity was in a fraction containing polyphenols other than anthocyanins. It was concluded that several peach and plum phenolic molecules can influence growth and differentiation in human colon cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkaline Phosphatase / biosynthesis
  • Alkaline Phosphatase / metabolism
  • Anthocyanins / pharmacology
  • Antioxidants / pharmacology
  • Caco-2 Cells
  • Cell Differentiation / drug effects
  • Cell Growth Processes / drug effects
  • Colonic Neoplasms / drug therapy*
  • Colonic Neoplasms / enzymology
  • Colonic Neoplasms / pathology*
  • Enzyme Induction / drug effects
  • Glucosides / pharmacology
  • HT29 Cells
  • Humans
  • Phenols / pharmacology*
  • Plant Extracts / pharmacology
  • Prunus / chemistry*


  • Anthocyanins
  • Antioxidants
  • Glucosides
  • Phenols
  • Plant Extracts
  • cyanidin-3-O-beta-glucopyranoside
  • cyanidin
  • Alkaline Phosphatase