The spectrum of mitochondrial mutation differs across species

PLoS Biol. 2008 Aug 26;6(8):e213. doi: 10.1371/journal.pbio.0060213.


Mitochondrial DNA mutation rates have now been measured in several model organisms. The patterns of mutation are strikingly different among species and point to modulation of mutation-selection balance in the evolution of nucleotide composition.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • DNA, Mitochondrial / genetics*
  • Humans
  • Mitochondria / genetics*
  • Mutation*
  • Species Specificity


  • DNA, Mitochondrial