Supplementation with active hexose correlated compound increases survival following infectious challenge in mice

Nutr Rev. 2008 Sep;66(9):526-31. doi: 10.1111/j.1753-4887.2008.00085.x.


Active hexose correlated compound (AHCC) is a fermented mushroom extract that is promoted for immune support. This review focuses on results from in vivo studies evaluating the effects of AHCC supplementation on survival and the immune response to a variety of infectious agents, including influenza virus, avian influenza virus, Klebsiella pneumoniae, Candida albicans, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus. Supplementation with AHCC appears to modulate immunity and increase survival in response to acute infection and warrants further investigation.

Publication types

  • Review

MeSH terms

  • Animals
  • Candidiasis / drug therapy
  • Candidiasis / immunology
  • Infections / immunology*
  • Infections / therapy*
  • Influenza A Virus, H1N1 Subtype
  • Influenza A Virus, H5N1 Subtype
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / immunology
  • Methicillin-Resistant Staphylococcus aureus
  • Mice
  • Opportunistic Infections / drug therapy
  • Opportunistic Infections / immunology
  • Orthomyxoviridae Infections / drug therapy
  • Orthomyxoviridae Infections / immunology
  • Polysaccharides / administration & dosage*
  • Pseudomonas Infections / drug therapy
  • Pseudomonas Infections / immunology
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / immunology
  • Survival Rate


  • Polysaccharides
  • Active Hexose Correlated Compound