Anti-atherogenic actions of high-density lipoprotein through sphingosine 1-phosphate receptors and scavenger receptor class B type I

Endocr J. 2009;56(3):317-34. doi: 10.1507/endocrj.k08e-228. Epub 2008 Aug 28.


Plasma high-density lipoprotein (HDL) is a potent anti-atherogenic factor, a critical role of which is thought to be reverse cholesterol transport through the lipoprotein-associated apolipoprotein A-I (apoA-I). HDL also carries a potent bioactive lipid mediator, sphingosine 1-phophate (S1P), which exerts diverse physiological and pathophysiological actions in a variety of biological systems, including the cardiovascular system. In addition, HDL-associated apoA-I is known to stimulate intracellular signaling pathways unrelated to transporter activity. Mounting evidence indicates that multiple antiatherogenic or anti-inflammatory actions of HDL independent of cholesterol metabolism are mediated by the lipoprotein-associated S1P through S1P receptors and by apoA-I through scavenger receptor class B type I.

Publication types

  • Review

MeSH terms

  • Animals
  • Apolipoprotein A-I / metabolism
  • Atherosclerosis / prevention & control*
  • Cardiovascular System / drug effects
  • Endothelial Cells / drug effects
  • Endothelial Cells / physiology
  • Humans
  • Lipoproteins, HDL / blood*
  • Lysophospholipids / metabolism
  • Receptors, Lysosphingolipid / metabolism*
  • Scavenger Receptors, Class B / physiology*
  • Signal Transduction
  • Sphingosine / analogs & derivatives
  • Sphingosine / metabolism


  • Apolipoprotein A-I
  • Lipoproteins, HDL
  • Lysophospholipids
  • Receptors, Lysosphingolipid
  • Scavenger Receptors, Class B
  • sphingosine 1-phosphate
  • Sphingosine