What's New in Rocky Mountain Spotted Fever?

Infect Dis Clin North Am. 2008 Sep;22(3):415-32, vii-viii. doi: 10.1016/j.idc.2008.03.008.


Rocky Mountain spotted fever (RMSF) remains an important illness despite an effective therapy because it is difficult to diagnose and is capable of producing a fatal outcome. The pathogenesis of RMSF remains, in large part, an enigma. However, recent research has helped shed light on this mystery. Importantly, the diagnosis of RMSF must be considered in all febrile patients who have known or possible exposure to ticks, especially if they live in or have traveled to endemic regions during warmer months. Decisions about giving empiric therapy to such patients are difficult and require skill and careful judgement.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use*
  • Diagnosis, Differential
  • Disease Reservoirs / microbiology
  • Disease Reservoirs / veterinary
  • Humans
  • Prognosis
  • Rickettsia rickettsii / growth & development
  • Rickettsia rickettsii / isolation & purification*
  • Rickettsia rickettsii / ultrastructure
  • Risk Factors
  • Rocky Mountain Spotted Fever / diagnosis*
  • Rocky Mountain Spotted Fever / drug therapy*
  • Rocky Mountain Spotted Fever / mortality
  • Rocky Mountain Spotted Fever / transmission
  • Ticks / microbiology*
  • Treatment Outcome
  • Virulence
  • Zoonoses


  • Anti-Bacterial Agents