Replication licensing and cancer--a fatal entanglement?

Nat Rev Cancer. 2008 Oct;8(10):799-806. doi: 10.1038/nrc2500. Epub 2008 Aug 29.


Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under- or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / metabolism*
  • Cell Transformation, Neoplastic*
  • DNA Damage
  • DNA Replication*
  • Humans
  • Mice
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Nuclear Proteins / metabolism*


  • Cell Cycle Proteins
  • Nuclear Proteins