[Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex]

Mol Gen Mikrobiol Virusol. 2008;(3):28-32.
[Article in Russian]

Abstract

Semax is a synthetic peptide, which consists of the N-terminal adrenocorticotropic hormone fragment (4-7) (ACTH4-7) and C-terminal Pro-Gly-Pro peptide. Semax promotes neuron survival in hypoxia, increases selective attention and memory storage. It was shown that this synthetic peptide exerted a number of gene expressions, especially brain derived neurotrophic factor gene (Bdnf) and nerve growth factor gene (Ngf). Temporary dynamics of Bdnf and Ngf ex- pression in rat hippocampus and frontal cortex under Semax action (50 mg/kg, single intranasal administration) was studied in this work. It was shown that the studied gene expression levels changed significantly both in the hippocampus and the frontal cortex tissues 20 minutes after the peptide preparation application. The expression levels decreased in the hippocampus and increased in the frontal cortex. Forty minutes after Semax administration both gene expression levels returned to the level typical of control tissues. After that they increased significantly by 90 minutes after experiment start. Bdnf and Ngf expression levels decreased up to the control levels by 8 hours after medicine applying maximum gene expression levels were attained. Thus, Semax administration results in rapid, long-term, and specific activation of Bdnf and Ngf expression changes in different rat brain departments.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenocorticotropic Hormone / analogs & derivatives*
  • Adrenocorticotropic Hormone / pharmacology
  • Animals
  • Brain-Derived Neurotrophic Factor / biosynthesis*
  • Cerebral Cortex / drug effects*
  • Cerebral Cortex / metabolism
  • Gene Expression
  • Hippocampus / drug effects*
  • Hippocampus / metabolism
  • Male
  • Nerve Growth Factors / biosynthesis*
  • Neuroprotective Agents / pharmacology*
  • Peptide Fragments / pharmacology*
  • Rats
  • Rats, Wistar

Substances

  • Brain-Derived Neurotrophic Factor
  • Nerve Growth Factors
  • Neuroprotective Agents
  • Peptide Fragments
  • ACTH (4-7), Pro-Gly-Pro-
  • Adrenocorticotropic Hormone