Airway epithelial cells: current concepts and challenges

Proc Am Thorac Soc. 2008 Sep 15;5(7):772-7. doi: 10.1513/pats.200805-041HR.


The adult human bronchial tree is covered with a continuous layer of epithelial cells that play a critical role in maintaining the conduit for air, and which are central to the defenses of the lung against inhaled environmental concomitants. The epithelial sheet functions as an interdependent unit with the other lung components. Importantly, the structure and/or function of airway epithelium is deranged in major lung disorders, including chronic obstructive pulmonary disease, asthma, and bronchogenic carcinoma. Investigations regarding the airway epithelium have led to many advances over the past few decades, but new developments in genetics and stem cell/progenitor cell biology have opened the door to understanding how the airway epithelium is developed and maintained, and how it responds to environmental stress. This article provides an overview of the current state of knowledge regarding airway epithelial stem/progenitor cells, gene expression, cell-cell interactions, and less frequent cell types, and discusses the challenges for future areas of investigation regarding the airway epithelium in health and disease.

Publication types

  • Review

MeSH terms

  • Cell Differentiation / physiology
  • Epithelial Cells / physiology*
  • Gene Expression
  • Humans
  • Respiratory Mucosa / cytology*
  • Respiratory Mucosa / physiology
  • Stem Cells / physiology*