Gamma knife radiosurgery for uveal melanoma: 12 years of experience

Br J Ophthalmol. 2009 Jan;93(1):40-4. doi: 10.1136/bjo.2008.142208. Epub 2008 Aug 29.


Aim: To present our treatment protocol and evaluate the results of Gamma knife radiosurgery (GKR) in treating patients with uveal melanoma.

Methods: Seventy-eight consecutive patients with uveal melanoma underwent stereotactic radiosurgery (radiation dose 30-50 Gy) with a Leksell Gamma-Knife at the San Raffaele University Hospital, Milan, Italy between 1994 and 2006. The main outcome measures evaluated were: survival rate, local tumour control, eye retention rate, visual acuity and treatment-related complications.

Results: Survival rate was 88.8% at 3 years and 81.9% at 5 years. Local tumour control was achieved in 91.0% of patients. The median tumour thickness reduction after treatment was 1.96 mm (p<0.0001) (-32.1%). The eye retention rate was 89.7%. A significant relative reduction of visual acuity was observed during follow-up. The most frequent treatment-related complications were: exudative retinopathy (33.3%), neovascular glaucoma (18.7%), radiogenic retinopathy (13.5%) and vitreous haemorrhages (10.4%).

Conclusion: GKR can be considered an alternative to enucleation for the treatment of choroidal melanomas.

Publication types

  • Evaluation Study

MeSH terms

  • Aged
  • Contrast Media
  • Female
  • Follow-Up Studies
  • Gadolinium
  • Humans
  • Kaplan-Meier Estimate
  • Magnetic Resonance Imaging / methods
  • Male
  • Melanoma / mortality
  • Melanoma / surgery*
  • Middle Aged
  • Radiosurgery* / mortality
  • Treatment Outcome
  • Uveal Neoplasms / mortality
  • Uveal Neoplasms / surgery*
  • Visual Acuity


  • Contrast Media
  • Gadolinium