Abstract
The inhibitory effects of three-component hybrid liposomes (HL) containing cationic lipids on the growth of human renal tumor cells were examined. Fifty percent inhibitory concentration of the three-component HL was remarkably reduced compared with that of dimyristoylphosphatidylcholine liposomes. The induction of apoptosis by the three-component HL without antitumor drugs was obtained for human renal tumor cells for the first time in this study.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carcinoma, Renal Cell / drug therapy*
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Carcinoma, Renal Cell / pathology
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Cations
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Cell Line, Tumor
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Drug Carriers
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Hemolysis / drug effects
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Humans
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Kidney Neoplasms / drug therapy*
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Kidney Neoplasms / pathology
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Lipids / administration & dosage*
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Lipids / chemistry*
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Lipids / pharmacology
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Liposomes / chemistry*
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Microscopy, Confocal
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Microscopy, Fluorescence
Substances
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Cations
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Drug Carriers
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Lipids
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Liposomes