Moebius syndrome is a rare congenital disorder characterized mainly by the inability to move the eyes laterally or produce facial expressions such as smiling. Moebius syndrome creates physical problems for the affected individual that may, in some cases, lead to emotional or social adjustment issues, yet the syndrome is relatively unknown among healthcare professionals. Because early recognition of Moebius syndrome can lead to early diagnosis and treatment, education of nurses in perinatal, pediatric, midwifery, and neonatal specialties is crucial. Through early recognition, maternal-child nurses can offer anticipatory guidance and provide or recommend resources to parents of children with this neurological condition.