Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases

Nat Rev Drug Discov. 2008 Sep;7(9):759-70. doi: 10.1038/nrd2638.

Abstract

Adenosine is a key endogenous molecule that regulates tissue function by activating four G-protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system express these receptors and are responsive to the modulatory effects of adenosine in an inflammatory environment. Animal models of asthma, ischaemia, arthritis, sepsis, inflammatory bowel disease and wound healing have helped to elucidate the regulatory roles of the various adenosine receptors in dictating the development and progression of disease. This recent heightened awareness of the role of adenosine in the control of immune and inflammatory systems has generated excitement regarding the potential use of adenosine-receptor-based therapies in the treatment of infection, autoimmunity, ischaemia and degenerative diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / drug therapy*
  • Autoimmune Diseases / physiopathology
  • Clinical Trials as Topic
  • Disease Models, Animal
  • Disease Progression
  • Humans
  • Inflammation / drug therapy*
  • Inflammation / physiopathology
  • Ischemia / drug therapy
  • Ischemia / physiopathology
  • Receptors, Purinergic P1 / drug effects*
  • Receptors, Purinergic P1 / immunology
  • Receptors, Purinergic P1 / metabolism
  • Signal Transduction

Substances

  • Receptors, Purinergic P1