Twisted epithelial-mesenchymal transition blocks senescence

Nat Cell Biol. 2008 Sep;10(9):1021-3. doi: 10.1038/ncb0908-1021.


The epithelial-mesenchymal transition (EMT) is a cellular transdifferentiation program that enables epithelial cancer cells to acquire traits of high-grade malignancy, notably invasive and metastatic powers. A new study indicates that it may also function early in tumour progression by preventing oncogene-induced senescence.

MeSH terms

  • Animals
  • Cellular Senescence*
  • Drug Resistance, Neoplasm
  • Epithelial Cells / pathology
  • Epithelium / pathology*
  • Humans
  • Mesoderm / pathology*
  • Mice
  • Neoplasms / pathology
  • Transcription Factors / metabolism*


  • Transcription Factors