Regulation of phosphate transport in proximal tubules

Pflugers Arch. 2009 May;458(1):39-52. doi: 10.1007/s00424-008-0580-8. Epub 2008 Aug 29.

Abstract

Homeostasis of inorganic phosphate (P(i)) is primarily an affair of the kidneys. Reabsorption of the bulk of filtered P(i) occurs along the renal proximal tubule and is initiated by apically localized Na(+)-dependent P(i) cotransporters. Tubular P(i) reabsorption and therefore renal excretion of P(i) is controlled by a number of hormones, including phosphatonins, and metabolic factors. In most cases, regulation of P(i) reabsorption is achieved by changing the apical abundance of Na(+)/Pi cotransporters. The regulatory mechanisms involve various signaling pathways and a number of proteins that interact with Na(+)/P(i) cotransporters.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acidosis / physiopathology
  • Animals
  • Cholecalciferol / physiology
  • Circadian Rhythm
  • Diet
  • Fibroblast Growth Factors / physiology
  • Gene Expression Regulation
  • Glucuronidase / physiology
  • Gonadal Steroid Hormones / physiology
  • Homeostasis
  • Humans
  • Ion Transport
  • Kidney Tubules, Proximal / metabolism*
  • Parathyroid Hormone / physiology
  • Phosphates / metabolism*
  • Phosphates / urine
  • Phosphoproteins / physiology
  • Potassium Deficiency / physiopathology
  • Signal Transduction
  • Sodium-Hydrogen Exchangers / physiology
  • Sodium-Phosphate Cotransporter Proteins / physiology*
  • Sodium-Phosphate Cotransporter Proteins, Type IIa / physiology
  • Sodium-Phosphate Cotransporter Proteins, Type IIc / physiology

Substances

  • Gonadal Steroid Hormones
  • Parathyroid Hormone
  • Phosphates
  • Phosphoproteins
  • SLC34A1 protein, human
  • SLC34A3 protein, human
  • Sodium-Hydrogen Exchangers
  • Sodium-Phosphate Cotransporter Proteins
  • Sodium-Phosphate Cotransporter Proteins, Type IIa
  • Sodium-Phosphate Cotransporter Proteins, Type IIc
  • sodium-hydrogen exchanger regulatory factor
  • Cholecalciferol
  • Fibroblast Growth Factors
  • fibroblast growth factor 23
  • Glucuronidase
  • klotho protein