Metabolic syndrome is associated with impaired health-related quality of life: Lapinlahti 2005 study

Qual Life Res. 2008 Oct;17(8):1055-62. doi: 10.1007/s11136-008-9386-6. Epub 2008 Aug 31.


Purpose: Association of Metabolic Syndrome (MetS) with Health-Related Quality of Life (HRQoL) is poorly documented. Our objective was to examine this association in an adult general population.

Methods: In our cross-sectional community-based health survey in a semirural Finnish community, we invited all the adults (n = 760) of eight birth cohorts between 30 and 65 years, of which 480 (63%) participated. A 15-dimensional, standardized HRQoL instrument (15D) was used to measure the main outcome, and the National Cholesterol Education Programme (NCEP) 2005 criteria were used for MetS classification.

Results: The prevalence of MetS was 38%. MetS was significantly associated with impaired HRQoL (P < 0.001) measured by the 15D score. Participants with MetS were statistically significantly worse off than participants without MetS in the dimensions of mobility (P < 0.001), hearing (P = 0.021), breathing (P < 0.001), usual activities (P = 0.001), discomfort and symptoms (P = 0.002), vitality (P = 0.003), and sexual activity (P = 0.008). In a logistic regression analysis, a significant association persisted between MetS and impaired HRQoL (OR = 1.9).

Conclusions: MetS seems to be associated closely with perceived HRQoL at community level. Therefore, reduction of risk factors of MetS may improve HRQoL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Psychological
  • Adult
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Confidence Intervals
  • Cross-Sectional Studies
  • Female
  • Finland / epidemiology
  • Humans
  • Logistic Models
  • Male
  • Metabolic Syndrome / epidemiology
  • Metabolic Syndrome / physiopathology
  • Metabolic Syndrome / psychology*
  • Middle Aged
  • Odds Ratio
  • Prevalence
  • Psychometrics
  • Quality of Life / psychology*
  • Social Perception
  • Surveys and Questionnaires