Association between sleep and physical function in older men: the osteoporotic fractures in men sleep study

J Am Geriatr Soc. 2008 Sep;56(9):1665-73. doi: 10.1111/j.1532-5415.2008.01846.x. Epub 2008 Aug 25.


Objectives: To determine whether sleep quality is associated with physical function in older men.

Design: Cross-sectional.

Setting: Six U.S. centers.

Participants: Two thousand eight hundred sixty-two community-dwelling men.

Measurements: Total hours of nighttime sleep (TST), wake after sleep onset (WASO), sleep latency (SL), and sleep efficiency (SE) measured using actigraphy; sleep stage distribution, respiratory disturbance index (RDI), and hypoxia measured using polysomnography; measures of physical function: grip strength, walking speed, chair stand, and narrow walk.

Results: In age-adjusted models, <6 or >8 hours TST, SE less than 80%, WASO of 90 minutes or longer, RDI of 30 or greater, and hypoxia were associated with poorer physical function. (Mean grip strength was 2.9% lower and mean walking speed was 4.3% lower in men with WASO >or=90 minutes than men with WASO <90 minutes.) After adjusting for potential covariates, differences in grip strength and walking speed remained significantly associated with WASO of 90 minutes or longer, SE less than 80%, and hypoxia but not with TST or RDI of 30 or greater.

Conclusion: Greater sleep fragmentation and hypoxia are associated with poorer physical function in older men.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Activities of Daily Living / classification*
  • Aged
  • Aged, 80 and over
  • Comorbidity
  • Disability Evaluation
  • Fractures, Spontaneous / diagnosis
  • Fractures, Spontaneous / epidemiology*
  • Geriatric Assessment / statistics & numerical data
  • Hand Strength
  • Health Surveys
  • Humans
  • Male
  • Mobility Limitation
  • Motor Activity
  • Osteoporosis / diagnosis
  • Osteoporosis / epidemiology*
  • Oxygen / blood
  • Polysomnography
  • Postural Balance
  • Sleep Wake Disorders / diagnosis
  • Sleep Wake Disorders / epidemiology*
  • Statistics as Topic
  • United States


  • Oxygen