Congenital adrenal hyperplasia causing clitoromegaly

J Coll Physicians Surg Pak. 2008 Jun;18(6):378-9.

Abstract

Congenital Adrenal Hyperplasia (CAH) is caused by congenital insufficiency of the enzyme 21 - hydroxylase (21-OHD) in the cortisol synthesis pathway. Because of the virilizing effects of androgens over-production, affected girls develop clitoral hypertrophy. Three patients with CAH are discussed below along with their surgical management and follow-up.

MeSH terms

  • Adolescent
  • Adrenal Hyperplasia, Congenital / pathology*
  • Adult
  • Child
  • Clitoris / pathology*
  • Female
  • Humans
  • Hypertrophy