SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion

Trends Cell Biol. 2008 Oct;18(10):486-93. doi: 10.1016/j.tcb.2008.07.005. Epub 2008 Aug 28.


Integrin adhesion is essential for aspects of immune function, including antigen presentation and migration in lymph nodes, germinal centers and sites of inflammation. Antigen receptors on B and T cells generate 'inside-out' signals for increased integrin clustering and adhesion. Although upstream components of B-cell-receptor or T-cell-receptor signaling are needed, the identity of key downstream effectors that mediate integrin adhesion is only just emerging. New candidates include immune-cell-specific adaptor proteins ADAP, SKAP-55 and SKAP-55-related (SKAP-55R). SKAP-55 has recently been identified as an effector in T cells in SKAP-55-deficient mice, whereas SKAP-55R is needed for B-cell adhesion. ADAP is required for SKAP-55 and SKAP-55R protein stability. SKAP-55 and SKAP-55R have unexpectedly specialized roles in T- and B-cell adhesion of the immune system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Cell Adhesion / immunology
  • Humans
  • Integrins / immunology
  • Integrins / metabolism*
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Lymphocyte Function-Associated Antigen-1 / immunology
  • Lymphocyte Function-Associated Antigen-1 / metabolism
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Mice
  • Phosphoproteins / genetics
  • Phosphoproteins / metabolism*
  • Receptors, Antigen, B-Cell / immunology
  • Receptors, Antigen, T-Cell / immunology
  • Receptors, Antigen, T-Cell / metabolism*


  • Adaptor Proteins, Signal Transducing
  • Fyb protein, mouse
  • Integrins
  • Intracellular Signaling Peptides and Proteins
  • Lymphocyte Function-Associated Antigen-1
  • Membrane Proteins
  • Phosphoproteins
  • Receptors, Antigen, B-Cell
  • Receptors, Antigen, T-Cell
  • SKAP55 protein, mouse
  • src kinase associated phosphoprotein 2