Abstract
Administering uridine-5'-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 days after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may partially restore dopaminergic neurotransmission in this model of Parkinson's disease.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Central Nervous System Stimulants / pharmacology
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Corpus Striatum / physiology
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Dextroamphetamine / pharmacology
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Docosahexaenoic Acids / therapeutic use*
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Dopamine / metabolism
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Functional Laterality / drug effects
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Injections
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Male
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Neostriatum / drug effects
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Neostriatum / metabolism
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Neostriatum / physiology
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Oxidopamine / administration & dosage
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Oxidopamine / toxicity
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Parkinson Disease, Secondary / chemically induced
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Parkinson Disease, Secondary / drug therapy*
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Rats
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Rats, Sprague-Dawley
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Stereotyped Behavior / drug effects
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Sympatholytics / administration & dosage
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Sympatholytics / toxicity
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Tyrosine 3-Monooxygenase / metabolism
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Uridine / therapeutic use*
Substances
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Central Nervous System Stimulants
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Sympatholytics
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Docosahexaenoic Acids
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Oxidopamine
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Tyrosine 3-Monooxygenase
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Dextroamphetamine
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Dopamine
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Uridine