Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease

Neurosci Res. 2008 Nov;62(3):206-9. doi: 10.1016/j.neures.2008.07.005. Epub 2008 Aug 3.

Abstract

Administering uridine-5'-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 days after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may partially restore dopaminergic neurotransmission in this model of Parkinson's disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Central Nervous System Stimulants / pharmacology
  • Corpus Striatum / physiology
  • Dextroamphetamine / pharmacology
  • Docosahexaenoic Acids / therapeutic use*
  • Dopamine / metabolism
  • Functional Laterality / drug effects
  • Injections
  • Male
  • Neostriatum / drug effects
  • Neostriatum / metabolism
  • Neostriatum / physiology
  • Oxidopamine / administration & dosage
  • Oxidopamine / toxicity
  • Parkinson Disease, Secondary / chemically induced
  • Parkinson Disease, Secondary / drug therapy*
  • Rats
  • Rats, Sprague-Dawley
  • Stereotyped Behavior / drug effects
  • Sympatholytics / administration & dosage
  • Sympatholytics / toxicity
  • Tyrosine 3-Monooxygenase / metabolism
  • Uridine / therapeutic use*

Substances

  • Central Nervous System Stimulants
  • Sympatholytics
  • Docosahexaenoic Acids
  • Oxidopamine
  • Tyrosine 3-Monooxygenase
  • Dextroamphetamine
  • Dopamine
  • Uridine