Monocyte chemoattractant protein-1: a key mediator in inflammatory processes

Int J Biochem Cell Biol. 2009 May;41(5):998-1001. doi: 10.1016/j.biocel.2008.07.018. Epub 2008 Aug 8.


Monocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant for monocytes and macrophages to areas of inflammation. MCP-1 is a prototypical chemokine subject to coordinated regulation by immunomodulatory agents. Since MCP-1 is implicated in multiple inflammatory diseases, it is a potential target for the treatment of these disorders. In this review, we will provide background information and summarize the MCP-1 structure and signaling pathways. Its involvement in multiple diseases, such as tumour development, atherogenesis and rare autoimmune diseases is also revised.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chemokine CCL2 / chemistry
  • Chemokine CCL2 / genetics
  • Chemokine CCL2 / immunology*
  • Humans
  • Inflammation / immunology


  • Chemokine CCL2