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Comparative Study
, 352 (6337), 689-95

Cloning of a Human Gene Encoding the General Transcription Initiation Factor IIB

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Comparative Study

Cloning of a Human Gene Encoding the General Transcription Initiation Factor IIB

I Ha et al. Nature.

Abstract

Transcription factor IIB (TFIIB) has a central role in transcription of class II genes. The purification of the human TFIIB protein and isolation of a complementary DNA encoding TFIIB activity is reported here. The sequence of TFIIB, which seems to be encoded by a single gene, contains a repeated motif, in addition to a motif with similarity to the prokaryotic sigma-factors. The recombinant protein expressed in bacteria substituted for all the functions attributed to the human TFIIB protein.

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