Cathepsin D: a cellular roadmap

Biochem Biophys Res Commun. 2008 Nov 7;376(1):5-9. doi: 10.1016/j.bbrc.2008.08.099. Epub 2008 Aug 30.


Cathepsin D is a normal and major component of lysosomes, it is found in almost all cells and tissues of mammals. Present review describes different events in cellular life of cathepsin D mainly its biosynthesis, co-translational and posttranslational modifications, targeting to lysosomes and proteolytic processing and maturation within lysosomes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cathepsin D / genetics*
  • Cathepsin D / metabolism*
  • Humans
  • Lysosomes / enzymology*
  • Neoplasms / enzymology
  • Neoplasms / ultrastructure
  • Protein Biosynthesis
  • Protein Processing, Post-Translational
  • Protein Transport
  • Transcription, Genetic


  • Cathepsin D