Objective: To investigate the effects of marine collagen peptide on adenine-induced chronic renal function impairment in rats.
Methods: Adenine suspension (100 mg/kg ) was given to Sprague-Dawley rats to made the model of renal function impairment. Marine collagen peptide 1.125 g x kg(-1) x d(-1) and 2.25 g x kg(-1) x d(-1) were administered intragastricly in two intervention groups. In addition, adenine suspension (100 mg/kg ) was given. Experiment was kept 12 weeks. Time-dependent levels of serum creatinine (Cr), urea nitrogen (BUN) and creatinine clearance rate were monitored. Kidney ultramicrostructure was checked through transmission electron microscope.
Results: In model group, level of serum Cr, BUN and Ccr of 5, 8, 12th week respectively were: (182.2 +/- 119.52, 308.17 +/- 88.37, 347.57 +/- 68.24; 29.20 +/- 16.48, 63.03 +/- 18.68, 95.53 +/- 24.88; 0.53 +/- 0.23, 0.17 +/- 0.13, 0.14 +/- 0.08). Serum Cr, BUN levels in marine collagen peptide 2.25 g x kg(-1) x d(-1) treated rats were lower and Ccr was higher significantly than that of model group. Level of serum Cr, BUN and Ccr of 5, 8, 12th week in marine collagen peptide treatment group respectively were: (105.60 +/- 11.84, 175.40 +/- 73.93, 240.14 +/- 71.53; 23.62 +/- 3.89, 41.90 +/- 23.78, 72.93 +/- 26.12; 0.99 +/- 0.35, 0.45 +/- 0.28, 0.26 +/- 0.06). Besides, kidney ultramicrostructure damage was ameliorated. Favorable effect of marine collagen peptide 1.125 g x kg(-1) x d(-1) was also observed on renal function impairment, but the difference compared to model group was not significant.
Conclusion: Marine collagen peptide at a dose of 2.25 g x kg(-1) x d(-1) might slow down the progression of chronic renal function impairment induced by adenine in rats.