Chronic pelvic pain syndrome and the overactive bladder: the inflammatory link

Curr Urol Rep. 2008 Jul;9(4):314-9. doi: 10.1007/s11934-008-0054-8.


Although the causes of chronic prostatitis/chronic pelvic pain syndrome, painful bladder syndrome/interstitial cystitis, and overactive bladder remain unclear, inflammation may explain some of the causative and propagating features. Cytokines may play a role by recruiting inflammatory cells and ultimately in inducing symptoms. This paper reviews the role of cytokines in the pathophysiology of chronic prostatitis/chronic pelvic pain syndrome, overactive bladder, and painful bladder syndrome/interstitial cystitis.

Publication types

  • Review

MeSH terms

  • Cytokines / physiology*
  • Humans
  • Inflammation / complications
  • Male
  • Prostatitis / etiology*
  • Urinary Bladder, Overactive / etiology*


  • Cytokines