A patient with antihistidyl-tRNA synthetase positive polymyositis presenting as acute respiratory distress syndrome

J Clin Rheumatol. 2008 Aug;14(4):219-21. doi: 10.1097/RHU.0b013e31817de0d4.


We describe an unusual case of a 48-year-old white woman diagnosed with positive antihistidyl-trna synthetase antibody polymyositis (PM) shortly after suffering from life-threatening acute respiratory distress syndrome (ARDS). In view of the fact that evaluation for infectious or noninfectious etiologies of ARDS was unrevealing, we reasoned that systemic inflammation in early subclinical PM may have precipitated alveolar-capillary membrane injury. One year after onset, PM has been maintained in remission with oral prednisone and azathioprine. This is the first report of a patient in whom ARDS was the presenting feature of anti-Jo-1 positive PM.

Publication types

  • Case Reports

MeSH terms

  • Antirheumatic Agents / therapeutic use
  • Autoantibodies / immunology*
  • Azathioprine / therapeutic use
  • Female
  • Histidine-tRNA Ligase / immunology*
  • Humans
  • Lung Diseases, Interstitial / complications
  • Middle Aged
  • Polymyositis / complications*
  • Polymyositis / diagnosis*
  • Polymyositis / drug therapy
  • Prednisone / therapeutic use
  • Respiratory Distress Syndrome / etiology*


  • Antirheumatic Agents
  • Autoantibodies
  • Histidine-tRNA Ligase
  • Azathioprine
  • Prednisone