Factors affecting survival in Alzheimer's disease

Psychol Med. 1991 May;21(2):363-70. doi: 10.1017/s0033291700020468.


Factors affecting survival of 178 patients diagnosed using NINCDS/ADRDA criteria for Alzheimer's disease were studied. All patients were drawn from the Camberwell Health Authority Area and so were a representative sample of subjects from a clinical old age psychiatry service. The mortality rate of the sample was 3.5 times that expected after adjustment for age. Younger subjects had a higher standardized mortality ratio than older subjects. The cumulative three-year mortality of the sample was 47%. Factors shown to be associated with a reduced survival included: increasing age, longer duration of illness, male sex, presence of physical illness, poor cognitive function, observed depression and absence of misidentification syndromes. Apraxia was a stronger predictor of early death than aphasia or dysmnesia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / mortality*
  • Alzheimer Disease / psychology
  • Apraxias / diagnosis
  • Apraxias / mortality
  • Apraxias / psychology
  • Female
  • Humans
  • Life Tables
  • Male
  • Neurologic Examination*
  • Neuropsychological Tests*
  • Poisson Distribution
  • Risk Factors
  • Survival Rate
  • Tomography, X-Ray Computed