Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy

J Cell Physiol. 2009 Jan;218(1):13-21. doi: 10.1002/jcp.21567.

Abstract

A critical regulator of the apoptotic machinery is the Bcl-2 family proteins whose over expression confers a protective effect on malignant cells against death signals of apoptosis. Cancer cells that are resistant to various anti-cancer drugs and treatment regimen are found to over express these Bcl-2 proteins such as Bcl-2, Bcl-X(L), Mcl-1, Bcl-w, and A1/Bfl1. In recent years there has been an exponential growth in the identification as well as synthesis of non-peptidic cell permeable small-molecule inhibitors (SMIs) of protein-protein interaction. The focus of this article is on inhibitors of anti-apoptotic protein Bcl-2. This review summarizes an up to date knowledge of the available SMIs, their mode of action as well as their current status in preclinical as well as clinical development.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aniline Compounds / pharmacology
  • Animals
  • Apoptosis / drug effects
  • Apoptosis / physiology
  • Benzamides / pharmacology
  • Binding Sites
  • Biphenyl Compounds / pharmacology
  • Gossypol / analogs & derivatives
  • Gossypol / pharmacology
  • Humans
  • Lymphoma / drug therapy
  • Models, Molecular
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Neoplasms / physiopathology
  • Nitrophenols / pharmacology
  • Piperazines / pharmacology
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors*
  • Proto-Oncogene Proteins c-bcl-2 / chemistry
  • Proto-Oncogene Proteins c-bcl-2 / classification
  • Proto-Oncogene Proteins c-bcl-2 / physiology
  • Pyrroles / pharmacology
  • Sulfonamides / pharmacology
  • Sulfones / pharmacology

Substances

  • ABT-737
  • Aniline Compounds
  • Benzamides
  • Biphenyl Compounds
  • Nitrophenols
  • Piperazines
  • Proto-Oncogene Proteins c-bcl-2
  • Pyrroles
  • Sulfonamides
  • Sulfones
  • TW-37 compound
  • Gossypol
  • obatoclax
  • navitoclax