Biodistribution and radiation dosimetry of [18F]F-PEB in nonhuman primates

Nucl Med Commun. 2008 Oct;29(10):915-9. doi: 10.1097/MNM.0b013e3283060c72.


Introduction: The metabotropic glutamate receptor subtype 5 (mGluR5) is distributed throughout the central nervous system (CNS), and has been suggested to be a potential target for several CNS disorders suchas Parkinson's disease, pain, anxiety, depression, schizophrenia, and addiction. We report here on the rhesus monkey biodistribution and radiation dosimetry of [18F]3-fluoro-5-[(pyridine-3-yl)ethynyl]benzonitrile, [18F]F-PEB, a mGluR5 positron emission tomography (PET) radiotracer.

Methods: Three male and two female rhesus monkeys were imaged using the Discovery ST PET/computed tomography scanner. A total of 25 whole body PET emissions were acquired over 3 h (23 emissions in one subject). Regions of interest were drawn in the brain, lungs, heart, liver, spleen, bladder, and testes. The absorbed radiation dose was calculated using OLINDA v1.

Results: At the end of the imaging session, 45% of the [18F]F-PEB activity had been excreted by the liver and into the gastrointestinal tract and 10% had been excreted into the urinary bladder. When extrapolating to the adult human, the largest absorbed radiation doses were located in the upper large intestine (males: 0.18 mGy/MBq, females: 0.20 mGy/MBq) and small intestine (males: 0.16 mGy/MBq, females: 0.19 mGy/MBq). Effective radiation dose was 0.033 mSv/MBq for males and 0.034 mSv/MBq for females, similar to many other [18F] ligands.

Conclusion: The effective radiation dose of [18F]F-PEB obtained from rhesus is similar to many other clinically utilized [18F] ligands.

MeSH terms

  • Animals
  • Female
  • Fluorine Radioisotopes
  • Humans
  • Macaca mulatta
  • Male
  • Nitriles / pharmacokinetics*
  • Positron-Emission Tomography
  • Pyridines / pharmacokinetics*
  • Radiometry
  • Radiopharmaceuticals / pharmacokinetics*
  • Receptors, Kainic Acid / metabolism
  • Tissue Distribution
  • Whole Body Imaging


  • 3-fluoro-5-((pyridin-3-yl)ethynyl)benzonitrile
  • Fluorine Radioisotopes
  • Gluk1 kainate receptor
  • Nitriles
  • Pyridines
  • Radiopharmaceuticals
  • Receptors, Kainic Acid