This Practice Point commentary discusses the findings and limitations of a cross-sectional survey by Nègre-Pagès et al. that investigated the prevalence of pain in a large number of patients with Parkinson disease (PD). The authors used a validated definition of chronic pain and included an age-matched and sex-matched control group. The study showed that chronic pain is a frequent but underreported symptom in PD, suggesting that awareness of this problem should be increased. This commentary highlights the issues to consider when interpreting these results, including the use of self-reported questionnaires and the classification of PD-associated pain. Overall, the findings indicate that interventions in patients with PD should go beyond the treatment of motor symptoms only and also target nonmotor symptoms; in particular, the treatment of pain needs to be improved.
Treatments for Parkinson disease--past achievements and current clinical needs.Neurology. 2009 Feb 17;72(7 Suppl):S65-73. doi: 10.1212/WNL.0b013e31819908ce. Neurology. 2009. PMID: 19221317 Review.
Nonmotor manifestations of Parkinson's disease.Ann Neurol. 2008 Dec;64 Suppl 2:S65-80. doi: 10.1002/ana.21472. Ann Neurol. 2008. PMID: 19127582 Review.
[Impact of motor and non-motor symptoms on the direct costs of Parkinson's disease].Neurologia. 2009 Jan-Feb;24(1):15-23. Neurologia. 2009. PMID: 19003550 Clinical Trial. Spanish.
Long-term outcome in Parkinson disease: no advantage to initiating therapy with dopamine agonists.Nat Clin Pract Neurol. 2008 Nov;4(11):590-1. doi: 10.1038/ncpneuro0934. Epub 2008 Oct 14. Nat Clin Pract Neurol. 2008. PMID: 18852725
Pain in Parkinson's disease: Prevalence and characteristics.Pain. 2009 Jan;141(1-2):173-7. doi: 10.1016/j.pain.2008.12.004. Epub 2008 Dec 18. Pain. 2009. PMID: 19100686