Aberrant signal transduction pathways in myeloproliferative neoplasms

Leukemia. 2008 Oct;22(10):1828-40. doi: 10.1038/leu.2008.236. Epub 2008 Sep 4.


The BCR-ABL-negative myeloproliferative neoplasms (MPNs), polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF), entered the spotlight in 2005 when the unique somatic acquired JAK2 V617F mutation was described in >95% of PV and in 50% of ET and PMF patients. For the very rare PV patients who do not harbor the JAK2 V617F mutation, exon 12 JAK2 mutants were discovered also to result in activated forms of JAK2. A minority of ET and PMF patients harbor mutations that constitutively activate the thrombopoietin receptor (TpoR). In bone marrow reconstitution models based on retroviral transduction, the phenotype induced by JAK2 V617F is less severe and different from the rapid fatal myelofibrosis induced by TpoR W515L. The reasons for these differences are unknown. Exactly by which mechanism(s) one acquired somatic mutation, JAK2 V617F, can promote three different diseases remains a mystery, although gene dosage and host genetic variation might have important functions. We review the recent progress made in deciphering signaling anomalies in PV, ET and PMF, with an emphasis on the relationship between JAK2 V617F and cytokine receptor signaling and on cross-talk with several other signaling pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Hematopoietic Stem Cells / physiology
  • Humans
  • Janus Kinase 2 / antagonists & inhibitors
  • Janus Kinase 2 / genetics
  • Janus Kinase 2 / physiology
  • Mutation
  • Phosphorylation
  • Polycythemia Vera / genetics*
  • Polycythemia Vera / physiopathology
  • Primary Myelofibrosis / genetics*
  • Primary Myelofibrosis / physiopathology
  • Receptors, Erythropoietin / physiology
  • Receptors, Granulocyte Colony-Stimulating Factor / physiology
  • Receptors, Thrombopoietin / physiology
  • STAT Transcription Factors / physiology
  • Signal Transduction*
  • Suppressor of Cytokine Signaling 3 Protein
  • Suppressor of Cytokine Signaling Proteins / physiology
  • Thrombocythemia, Essential / genetics*
  • Thrombocythemia, Essential / physiopathology
  • Transforming Growth Factor beta / physiology
  • Tumor Necrosis Factor-alpha / physiology


  • Receptors, Erythropoietin
  • Receptors, Granulocyte Colony-Stimulating Factor
  • Receptors, Thrombopoietin
  • SOCS3 protein, human
  • STAT Transcription Factors
  • Suppressor of Cytokine Signaling 3 Protein
  • Suppressor of Cytokine Signaling Proteins
  • Transforming Growth Factor beta
  • Tumor Necrosis Factor-alpha
  • MPL protein, human
  • JAK2 protein, human
  • Janus Kinase 2