Diagnosis and treatment of unexplained infertility

Rev Obstet Gynecol. 2008 Spring;1(2):69-76.


Over the past decade, significant advances have occurred in the diagnosis and treatment of reproductive disorders. In this review, we discuss the routine testing performed to diagnose unexplained infertility. We also discuss additional testing, such as assessment of ovarian reserve, and the potential role of laparoscopy in the complete workup of unexplained infertility. Finally, we outline the available therapeutic options and discuss the efficacy and the cost-effectiveness of the existing treatment modalities. The optimal treatment strategy needs to be based on individual patient characteristics such as age, treatment efficacy, side-effect profile, and cost considerations.

Keywords: Controlled ovarian hyperstimulation; In vitro fertilization; Infertility, unexplained; Intrauterine insemination; Ovarian reserve; Ovulation assessment; Semen analysis.