Isolation and characterization of low-molecular-weight chromium-binding substance (LMWCr) from chicken liver

Protein J. 2008 Sep;27(6):371-5. doi: 10.1007/s10930-008-9146-z.


Chromodulin (also known as low-molecular-weight chromium-binding substance, LMWCr) is a chromium-binding oligopeptide proposed to play a role in insulin signaling and chromium transport in mammals. This laboratory has isolated and purified this material from a non-mammalian source, an avian. Spectroscopic and physical characterization of the isolated material suggests the material is an oligopeptide with a multinuclear chromium assembly bridged via asparatate and glutamate residues very similar to its mammalian counterparts. The isolated material also possesses a biological activity similar to other LMWCr isolates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carrier Proteins / chemistry*
  • Carrier Proteins / isolation & purification*
  • Carrier Proteins / metabolism
  • Chickens
  • Chromium / metabolism*
  • Electrophoresis, Polyacrylamide Gel
  • Insulin / metabolism
  • Liver Extracts / chemistry*
  • Molecular Weight
  • Protein Binding


  • Carrier Proteins
  • Insulin
  • Liver Extracts
  • chromodulin protein, human
  • Chromium