Is hsp70 the cellular thermometer?

Trends Biochem Sci. 1991 Apr;16(4):135-40. doi: 10.1016/0968-0004(91)90055-z.


Cells respond to an increase in temperature by inducing the synthesis of the heat shock proteins, which are a small set of evolutionarily conserved proteins. We review the evidence leading us to suggest that the free pool of one of these proteins, hsp70, serves as a cellular thermometer that regulates the expression of all heat shock proteins.

Publication types

  • Review

MeSH terms

  • Animals
  • Eukaryotic Cells / physiology*
  • Heat-Shock Proteins / physiology*
  • Prokaryotic Cells / physiology*
  • Temperature*


  • Heat-Shock Proteins