Desaturase activities and metabolic control in type 2 diabetes

Prostaglandins Leukot Essent Fatty Acids. Jul-Aug 2008;79(1-2):55-8. doi: 10.1016/j.plefa.2008.07.001. Epub 2008 Sep 3.

Abstract

The aim of this study was to elucidate the effects of a poor glycemic control on fatty acid composition and desaturase activities in type 2 diabetic patients. Plasma phospholipid fatty acid composition and desaturase activities (estimated from fatty acid product to precursor ratios) were measured in 30 type 2 diabetic patients during poor metabolic control and after achieving a good metabolic control. Significant changes were recorded in the percentages of palmitic, stearic, dihomo-gamma-linolenic, docosatetraenoic and docosapentaenoic acid. The delta-5 desaturase activity was significantly higher with poor than with good metabolic control. The changes identified in plasma phospholipid fatty acid composition and the desaturase activity in type 2 diabetic patients go in the opposite direction to those described in similar conditions in type 1 diabetic patients and may be relevant to a better understanding of the role of metabolic control in the progression of chronic complications in type 2 diabetic patients.

Publication types

  • Clinical Trial

MeSH terms

  • Blood Glucose / drug effects
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / metabolism*
  • Enzyme Activation
  • Fatty Acid Desaturases / blood
  • Fatty Acid Desaturases / metabolism*
  • Fatty Acids / blood
  • Female
  • Glycated Hemoglobin A
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Insulin / therapeutic use
  • Male
  • Metformin / therapeutic use
  • Middle Aged
  • Phospholipids / blood
  • Reproducibility of Results

Substances

  • Blood Glucose
  • Fatty Acids
  • Glycated Hemoglobin A
  • Hypoglycemic Agents
  • Insulin
  • Phospholipids
  • hemoglobin A1c protein, human
  • Metformin
  • Fatty Acid Desaturases