Mutually exclusive var gene expression in the malaria parasite: multiple layers of regulation

Trends Parasitol. 2008 Oct;24(10):455-61. doi: 10.1016/j.pt.2008.07.005. Epub 2008 Sep 2.

Abstract

As a major factor in Plasmodium falciparum malaria pathogenesis, the var gene family has been the focus of extensive research, which has contributed to our current understanding of Plasmodium antigenic variation. In recent years, sophisticated molecular tools have enabled the generation of interesting data regarding the regulation of mutually exclusive var expression. Although their results are still inconclusive, these studies have demonstrated the existence of multiple layers of control over gene activation, silencing, memory and 'counting'. This review attempts to summarize recent findings and dissect the different layers of var regulation.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigenic Variation
  • Antigens, Protozoan / genetics
  • Chromatin / genetics
  • DNA, Protozoan / genetics*
  • Gene Expression Regulation*
  • Gene Silencing
  • Genes, Protozoan / genetics*
  • Plasmodium falciparum / genetics*
  • Plasmodium falciparum / pathogenicity
  • Protozoan Proteins / genetics*
  • Transcription, Genetic
  • Virulence / genetics

Substances

  • Antigens, Protozoan
  • Chromatin
  • DNA, Protozoan
  • Protozoan Proteins
  • erythrocyte membrane protein 1, Plasmodium falciparum