Comparison of navigated 3D ultrasound findings with histopathology in subsequent phases of glioblastoma resection

Acta Neurochir (Wien). 2008 Oct;150(10):1033-41; discussion 1042. doi: 10.1007/s00701-008-0017-3. Epub 2008 Sep 5.


Objective: The purpose of the study was to compare the ability of navigated 3D ultrasound to distinguish tumour and normal brain tissue at the tumour border zone in subsequent phases of resection.

Materials and methods: Biopsies were sampled in the tumour border zone as seen in the US images before and during surgery. After resection, biopsies were sampled in the resection cavity wall. Histopathology was compared with the surgeon's image findings.

Results: Before resection, the tumour border was delineated by ultrasound with high specificity and sensitivity (both 95%). During resection, ultrasound had acceptable sensitivity (87%), but poor specificity (42%), due to biopsies falsely classified as tumour by the surgeon. After resection, sensitivity was poor (26%), due to tumour or infiltrated tissue in several biopsies deemed normal by ultrasound, but the specificity was acceptable (88%).

Conclusions: Our study shows that although glioblastomas are well delineated prior to resection, there seem to be overestimation of tumour tissue during resection. After resection tumour remnants and infiltrated brain tissue in the resection cavity wall may be undetected. We believe that the benefits of intraoperative ultrasound outweigh the shortcomings, but users of intraoperative ultrasound should keep the limitations shown in our study in mind.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biopsy
  • Brain / pathology
  • Brain / surgery
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / pathology
  • Brain Neoplasms / surgery*
  • Diagnostic Errors / prevention & control
  • Diagnostic Errors / statistics & numerical data
  • Female
  • Glioblastoma / diagnostic imaging
  • Glioblastoma / pathology
  • Glioblastoma / surgery*
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Imaging, Three-Dimensional / methods
  • Male
  • Middle Aged
  • Monitoring, Intraoperative / methods
  • Neuronavigation / methods*
  • Neurosurgical Procedures / methods
  • Predictive Value of Tests
  • Stereotaxic Techniques
  • Ultrasonography, Doppler, Transcranial / methods*