Preliminary evaluation: the effects of Aloe ferox Miller and Aloe arborescens Miller on wound healing

J Ethnopharmacol. 2008 Nov 20;120(2):181-9. doi: 10.1016/j.jep.2008.08.008. Epub 2008 Aug 15.


Aim of the study: Genus Aloe has been traditionally utilized for medicinal purpose for decades. Compared with Aloe vera gel, the qualitative assessment for the therapeutic effects of the other two Aloe species, Aloe ferox Miller and Aloe arborescens Miller, for their topical wound healing was less addressed. Therefore, the aim of present study is to provide the positive evidence for Aloe ferox Miller and Aloe arborescens Miller supporting their therapeutic properties for topical treatment of skin wounds.

Materials and methods: Two types of the whole-leaf juice prepared from either Aloe ferox Miller or Aloe arborescens Miller were used in this study. Incision wound healing was investigated using both the rat and rabbit model. The wound closure rate with and without the topical administration of the whole-leaf juice were monitored. The changes in wound characteristics were traced and wound severity was scored on different days. The anti-microorganism actions of each whole-leaf juice preparation were evaluated by measuring their inhibition growth effects on four bacterial strains and three fungal spores. The toxic influence owing to topical application of Aloe whole-leaf juice on intact and damaged skin was also assessed.

Results and conclusions: Our results indicated that the two types of whole-leaf juice preparations exhibit the therapeutic properties, including facilitation of the healing process, selective inhibition of the microbial growth and zero side-effect on the skin, during the observation period. It is concluded that both of Aloe whole-leaf juice preparations have the positive potential for skin medicinal application.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Aloe / chemistry*
  • Animals
  • Anti-Infective Agents / administration & dosage
  • Anti-Infective Agents / isolation & purification
  • Anti-Infective Agents / toxicity
  • Bacteria / drug effects
  • Disease Models, Animal
  • Guinea Pigs
  • Male
  • Mice
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / toxicity
  • Plant Leaves
  • Rabbits
  • Rats
  • Rats, Wistar
  • Severity of Illness Index
  • Skin / drug effects*
  • Skin / injuries
  • Spores, Fungal / drug effects
  • Toxicity Tests
  • Wound Healing / drug effects*


  • Anti-Infective Agents
  • Plant Extracts