Comparison of Fourier-domain and time-domain optical coherence tomography in the detection of band atrophy of the optic nerve

Am J Ophthalmol. 2009 Jan;147(1):56-63.e2. doi: 10.1016/j.ajo.2008.07.020. Epub 2008 Sep 6.


Purpose: To compare the ability of Fourier-domain (FD) optical coherence tomography (3D OCT-1000; Topcon, Tokyo, Japan) and time-domain (TD) OCT (Stratus; Carl Zeiss Meditec Inc, Dublin, California, USA) to detect axonal loss in eyes with band atrophy (BA) of the optic nerve.

Design: Cross-sectional study.

Methods: Thirty-six eyes from 36 patients with BA and temporal visual field (VF) defect from chiasmal compression and 36 normal eyes were studied. Subjects were submitted to standard automated perimetry and macular and retinal nerve fiber layer (RNFL) measurements were taken using 3D OCT-1000 and Stratus OCT. Receiver operating characteristic (ROC) curves were calculated for each parameter. Spearman correlation coefficients were obtained to evaluate the relationship between RNFL and macular thickness parameters and severity of VF loss. Measurements from the two devices were compared.

Results: Regardless of OCT device, all RNFL and macular thickness parameters were significantly lower in eyes with BA compared with normal eyes, but no statistically significant difference was found with regard to the area under the ROC curve. Structure-function relationships were also similar for the two devices. In both groups, RNFL and macular thickness measurements were generally and in some cases significantly smaller with 3D OCT-1000 than with Stratus OCT.

Conclusions: The introduction of FD technology did not lead to better discrimination ability for detecting BA of the optic nerve compared with TD technology when using the software currently provided by the manufacturer. 3D OCT-1000 FD OCT RNFL and macular measurements were generally smaller than TD Stratus OCT measurements. Investigators should be aware of this fact when comparing measurements obtained with these two devices.

Trial registration: NCT00607100.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma / pathology
  • Adult
  • Aged
  • Axons / pathology*
  • Craniopharyngioma / pathology
  • Cross-Sectional Studies
  • Female
  • Fourier Analysis
  • Hemianopsia / diagnosis
  • Humans
  • Imaging, Three-Dimensional
  • Male
  • Middle Aged
  • Optic Atrophy / diagnosis*
  • Pituitary Neoplasms / pathology
  • Prospective Studies
  • ROC Curve
  • Time Factors
  • Tomography, Optical Coherence / methods*
  • Vision Disorders / diagnosis
  • Visual Field Tests
  • Visual Fields

Associated data