PtdIns5P regulation through evolution: roles in membrane trafficking?

Trends Biochem Sci. 2008 Oct;33(10):453-60. doi: 10.1016/j.tibs.2008.07.002. Epub 2008 Sep 5.


Phosphoinositides are lipid second messengers that are essential for many cellular processes, including signal transduction and cell compartmentalization. Among them, phosphatidylinositol 5-phosphate (PtdIns5P) is the least characterized, although several proteins involved in its regulation are implicated in human diseases. We studied the distribution of 32 PtdIns5P-metabolizing proteins in 39 eukaryotic genomes. Phylogenetic profiles identify four groups of co-evolving proteins, confirming known protein complexes and revealing new ones. The complexes comprise a phosphatase, a kinase and a regulator; this indicates that physical interactions between the three partners are necessary for the acute spatial regulation of PtdIns5P turnover. By examining PtdIns5P metabolism in this new perspective, we propose a role for PtdIns5P in membrane trafficking from late endosomal compartments to the plasma membrane.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Evolution, Molecular*
  • Genomics
  • Humans
  • Phosphatidylinositol Phosphates / metabolism
  • Phosphatidylinositol Phosphates / physiology*
  • Phosphatidylinositols / physiology
  • Phosphorylation
  • Phosphotransferases / metabolism
  • Phylogeny
  • Second Messenger Systems
  • Signal Transduction


  • Phosphatidylinositol Phosphates
  • Phosphatidylinositols
  • phosphatidylinositol 5-phosphate
  • Phosphotransferases